IGHVIII-26-1

Across TCGA patient cohorts, IGHVIII-26-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,657 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHVIII-26-1-associated GO terms across cancer lineages are Regulation of pattern recognition receptor signaling pathway, Proton transmembrane transport, and Endoplasmic reticulum to cytosol transport. Each is linked with IGHVIII-26-1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHVIII-26-1-to-partner and partner-to-IGHVIII-26-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of pattern recognition receptor signaling pathway grouped by IGHVIII-26-1-low versus IGHVIII-26-1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-26-1→partner) and Y-score (partner→IGHVIII-26-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of pattern recognition receptor signaling pathway →	+0.115	+0.031	<.001	<.001	3	6
ESCA	Proton transmembrane transport →	+0.121	+0.034	<.001	<.001	3	5
ESCA	Endoplasmic reticulum to cytosol transport →	+0.136	+0.050	<.001	.001	3	5
ESCA	B cell activation involved in immune response →	+0.112	+0.029	<.001	.001	3	5
ESCA	T cell receptor signaling pathway →	+0.135	+0.027	<.001	.002	3	5
ESCA	Negative regulation of secretion →	+0.070	+0.025	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,657 associations by consensus.

Regulation of pattern recognition receptor signaling pathway by IGHVIII-26-1 expression — ESCA

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