IGHVIII-26-1

Across TCGA pan-cancer cohorts, IGHVIII-26-1 RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated IGHVIII-26-1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher IGHVIII-26-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-26-1 expression acts as an unfavorable survival marker.

ACC, SKCM, and KIRC are the cancer types where IGHVIII-26-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.010	0.667	<.001	135	view →
SKCM	DFS	Tertile	III,IV	0.144	0.600	.007	51	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	48	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
UCEC	DFS	Tertile	All	0.106	0.649	<.001	36	view →
COAD	DFS	Tertile	III,IV	0.170	0.697	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IGHVIII-26-1–ACC (DFS)

Open the ACC breakdown →