IGHVIII-25-1

Across TCGA patient cohorts, IGHVIII-25-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,065 significant associations in total. THYM shows the largest number of these associations.

The most reproducible IGHVIII-25-1-associated GO terms across cancer lineages are B cell mediated immunity, T cell activation involved in immune response, and Mature B cell differentiation. Each is linked with IGHVIII-25-1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGHVIII-25-1-to-partner and partner-to-IGHVIII-25-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHVIII-25-1-low versus IGHVIII-25-1-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-25-1→partner) and Y-score (partner→IGHVIII-25-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.102	+0.050	<.001	<.001	3	13
LIHC	T cell activation involved in immune response →	+0.052	+0.024	<.001	.002	3	11
STAD	Mature B cell differentiation →	+0.070	+0.040	<.001	<.001	3	11
STAD	B cell receptor signaling pathway →	+0.097	+0.051	<.001	<.001	3	11
THCA	Humoral immune response →	+0.066	+0.046	<.001	<.001	3	10
STAD	Mature B cell differentiation involved in immune response →	+0.063	+0.032	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,065 associations by consensus.

B cell mediated immunity by IGHVIII-25-1 expression — THCA

Explore this box plot interactively →