IGHVIII-25-1

Across TCGA pan-cancer cohorts, IGHVIII-25-1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGHVIII-25-1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGHVIII-25-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-25-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and THYM show a favorable association.

LUSC, STAD, and KIRP are the cancer types where IGHVIII-25-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.329	0.638	<.001	111	view →
STAD	DFS	Tertile	All	0.295	0.722	.001	87	view →
KIRP	DFS	Tertile	II,III,IV	0.159	0.693	.003	45	view →
ESCA	OS	Tertile	All	0.198	0.872	.003	36	view →
BLCA	DFS	Tertile	IV	0.152	0.486	.002	36	view →
LUAD	DFS	Tertile	II,III,IV	0.839	0.498	.003	18	view →
KIRC	DFS	Tertile	IV	0.147	0.639	.009	18	view →
THYM	OS	Median	All	0.983	0.766	.017	11	view →
LIHC	DFS	Tertile	II,III,IV	0.100	0.463	.048	9	view →
SKCM	OS	Tertile	III,IV	1.000	0.362	.028	9	view →
SARC	DFS	Tertile	All	0.153	0.594	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGHVIII-25-1–LUSC (DFS)

Open the LUSC breakdown →