IGHVIII-22-2

Across TCGA pan-cancer cohorts, IGHVIII-22-2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHVIII-22-2 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGHVIII-22-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-22-2 expression acts as an unfavorable survival marker, although some lineages such as COAD and PAAD show a favorable association.

KIRP, STAD, and DLBC are the cancer types where IGHVIII-22-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.177	0.840	<.001	96	view →
STAD	DFS	Tertile	IV	0.057	0.546	.001	90	view →
DLBC	OS	Tertile	III,IV	0.172	0.907	<.001	36	view →
KIRC	DFS	Tertile	IV	0.198	0.629	.002	36	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
COAD	DFS	Tertile	All	0.918	0.672	.010	24	view →
PAAD	OS	Tertile	II,III,IV	1.000	0.512	.010	21	view →
LUAD	DFS	Tertile	IV	0.047	0.565	<.001	18	view →
THYM	OS	Median	II,III,IV	0.931	0.670	.005	16	view →
LUSC	DFS	Tertile	II,III,IV	0.488	0.774	.028	9	view →
LGG	OS	Tertile	All	0.503	0.889	.013	9	view →
LIHC	OS	Tertile	All	0.105	0.774	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHVIII-22-2–KIRP (DFS)

Open the KIRP breakdown →