IGHVIII-22-2

Across TCGA pan-cancer cohorts, IGHVIII-22-2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVIII-22-2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHVIII-22-2 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVIII-22-2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD and HNSC are the cancer types where IGHVIII-22-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIII-22-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.758	<.001	7	view →
HNSC	Male	III,IV	−0.344	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVIII-22-2–COAD

Open the COAD breakdown →