IGHVIII-2-1

Across TCGA pan-cancer cohorts, IGHVIII-2-1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGHVIII-2-1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher IGHVIII-2-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-2-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

KICH, KIRP, and READ are the cancer types where IGHVIII-2-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.102	0.848	.004	39	view →
KIRP	DFS	Tertile	II,III,IV	0.167	0.693	.007	27	view →
READ	OS	Tertile	III,IV	0.597	0.911	.004	24	view →
LIHC	OS	Tertile	All	0.156	0.774	.005	24	view →
LUAD	DFS	Tertile	II,III,IV	0.779	0.522	.023	12	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
LUSC	DFS	Tertile	III,IV	0.986	0.614	.028	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHVIII-2-1–KICH (DFS)

Open the KICH breakdown →