IGHVIII-2-1

Across TCGA pan-cancer cohorts, IGHVIII-2-1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IGHVIII-2-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHVIII-2-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVIII-2-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD are the cancer types where IGHVIII-2-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIII-2-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.090	.008	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

IGHVIII-2-1–COAD

Open the COAD breakdown →