IGHVIII-13-1

Across TCGA pan-cancer cohorts, IGHVIII-13-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVIII-13-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IGHVIII-13-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVIII-13-1 is over-expressed in tumor.

LUSC and KIRC are the cancer types where IGHVIII-13-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVIII-13-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.061	.036	1	view →
KIRC	All	All	+0.021	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVIII-13-1–LUSC

Open the LUSC breakdown →