IGHVIII-11-1

Across TCGA patient cohorts, IGHVIII-11-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,089 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHVIII-11-1-associated GO terms across cancer lineages are Antigen receptor-mediated signaling pathway, B cell receptor signaling pathway, and Leukocyte apoptotic process. Each is linked with IGHVIII-11-1 in more than 17 cancer types. Because this analysis shows association rather than direction, both IGHVIII-11-1-to-partner and partner-to-IGHVIII-11-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen receptor-mediated signaling pathway grouped by IGHVIII-11-1-low versus IGHVIII-11-1-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVIII-11-1→partner) and Y-score (partner→IGHVIII-11-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Antigen receptor-mediated signaling pathway →	+0.099	+0.106	<.001	.004	2	18
PAAD	B cell receptor signaling pathway →	+0.140	+0.076	<.001	.003	3	17
PAAD	Leukocyte apoptotic process →	+0.062	+0.149	<.001	.002	2	17
THCA	Immunoglobulin production →	+0.084	+0.040	<.001	<.001	3	16
PAAD	Regulation of B cell activation →	+0.069	+0.084	<.001	.001	3	15
PAAD	T cell selection →	+0.097	+0.153	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,089 associations by consensus.

Antigen receptor-mediated signaling pathway by IGHVIII-11-1 expression — PAAD

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