IGHVIII-11-1

Across TCGA pan-cancer cohorts, IGHVIII-11-1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHVIII-11-1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGHVIII-11-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVIII-11-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCS, UCEC, and OV are the cancer types where IGHVIII-11-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	All	0.068	0.524	<.001	144	view →
UCEC	OS	Tertile	III,IV	0.053	0.588	.005	54	view →
OV	OS	Tertile	III,IV	0.628	0.839	.033	42	view →
STAD	DFS	Tertile	All	0.406	0.586	.010	27	view →
READ	DFS	Tertile	All	0.084	0.845	<.001	18	view →
THCA	OS	Tertile	II,III,IV	0.173	0.903	.011	18	view →
HNSC	DFS	Tertile	All	0.745	0.588	.027	9	view →
KIRP	DFS	Tertile	All	0.624	0.902	.039	6	view →
LUAD	DFS	Tertile	All	0.743	0.645	.024	6	view →
KIRC	DFS	Tertile	IV	0.882	0.525	.046	6	view →
THYM	OS	Median	All	0.956	0.610	.015	5	view →
LIHC	DFS	Tertile	II,III,IV	0.875	0.412	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHVIII-11-1–UCS (DFS)

Open the UCS breakdown →