IGHVII-78-1

Across TCGA pan-cancer cohorts, IGHVII-78-1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGHVII-78-1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher IGHVII-78-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-78-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and THCA are the cancer types where IGHVII-78-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.104	0.858	<.001	99	view →
HNSC	DFS	Tertile	II,III,IV	0.830	0.659	.006	96	view →
THCA	OS	Tertile	III,IV	0.887	0.985	.001	57	view →
KIRC	DFS	Quartile	All	0.948	0.860	.004	46	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
SKCM	DFS	Tertile	All	0.593	0.187	.001	33	view →
ESCA	OS	Quartile	All	0.557	1.000	.007	21	view →
LIHC	OS	Quartile	II,III,IV	0.232	0.443	.005	19	view →
LUAD	DFS	Median	IV	0.215	0.698	.011	12	view →
COAD	OS	Tertile	IV	0.885	0.308	.015	11	view →
KICH	DFS	Tertile	III,IV	0.043	0.897	.045	9	view →
DLBC	DFS	Median	III,IV	0.885	0.364	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGHVII-78-1–UVM (OS)

Open the UVM breakdown →