IGHVII-78-1

Across TCGA pan-cancer cohorts, IGHVII-78-1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IGHVII-78-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where IGHVII-78-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVII-78-1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where IGHVII-78-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-78-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.547	<.001	7	view →
KIRC	Male	All	−0.311	<.001	6	view →
LUAD	Male	All	+0.758	<.001	5	view →
COAD	All	II,III,IV	+0.605	<.001	5	view →
ESCA	All	II,III,IV	+1.410	.011	2	view →
PAAD	All	All	+0.702	.012	2	view →
PRAD	All	All	+0.155	.027	2	view →
LIHC	All	All	+0.101	.027	2	view →
BLCA	All	IV	+0.501	.039	1	view →
CHOL	All	All	+0.427	.022	1	view →
STAD	Female	III,IV	−0.325	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IGHVII-78-1–KICH

Open the KICH breakdown →