IGHVII-53-1

Across TCGA pan-cancer cohorts, IGHVII-53-1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGHVII-53-1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher IGHVII-53-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-53-1 expression acts as an unfavorable survival marker, although some lineages such as LAML and HNSC show a favorable association.

MESO, LAML, and THCA are the cancer types where IGHVII-53-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
LAML	DFS	Tertile	All	0.785	0.539	.021	36	view →
THCA	DFS	Tertile	II,III,IV	0.702	0.937	.001	27	view →
HNSC	DFS	Tertile	III,IV	0.860	0.649	.005	24	view →
LUSC	DFS	Tertile	II,III,IV	0.803	0.677	.008	19	view →
STAD	OS	Tertile	IV	0.805	0.283	.031	18	view →
COAD	OS	Tertile	IV	0.364	0.693	.030	18	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	18	view →
BLCA	OS	Tertile	All	0.827	0.595	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGHVII-53-1–MESO (OS)

Open the MESO breakdown →