IGHVII-53-1

Across TCGA pan-cancer cohorts, IGHVII-53-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVII-53-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where IGHVII-53-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVII-53-1 is over-expressed in tumor.

LUSC and HNSC are the cancer types where IGHVII-53-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-53-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	III,IV	+0.350	.003	3	view →
HNSC	Male	All	+0.048	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVII-53-1–LUSC

Open the LUSC breakdown →