IGHVII-51-2

Across TCGA pan-cancer cohorts, IGHVII-51-2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGHVII-51-2 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher IGHVII-51-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVII-51-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

UCS, OV, and HNSC are the cancer types where IGHVII-51-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	IV	0.132	0.718	.002	108	view →
OV	OS	Tertile	III,IV	0.432	0.691	<.001	90	view →
HNSC	DFS	Tertile	III,IV	0.832	0.643	.002	75	view →
BRCA	OS	Tertile	All	0.990	0.958	.007	69	view →
LUAD	OS	Quartile	II,III,IV	0.940	0.667	.001	38	view →
KIRP	DFS	Tertile	III,IV	0.040	0.691	<.001	27	view →
LUSC	OS	Quartile	III,IV	0.400	0.614	.024	19	view →
BLCA	OS	Tertile	IV	0.900	0.290	.006	18	view →
COAD	OS	Tertile	III,IV	0.612	0.836	.007	18	view →
SKCM	DFS	Tertile	III,IV	0.433	0.217	.019	12	view →
PCPG	DFS	Tertile	All	0.535	0.936	.005	9	view →
READ	DFS	Tertile	IV	0.917	0.486	.036	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGHVII-51-2–UCS (DFS)

Open the UCS breakdown →