IGHVII-51-2

Across TCGA pan-cancer cohorts, IGHVII-51-2 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHVII-51-2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHVII-51-2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVII-51-2 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

LUAD, STAD, and HNSC are the cancer types where IGHVII-51-2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-51-2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.271	<.001	4	view →
STAD	All	All	−0.458	.015	2	view →
HNSC	Male	II,III,IV	+0.057	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGHVII-51-2–LUAD

Open the LUAD breakdown →