IGHVII-49-1

Across TCGA pan-cancer cohorts, IGHVII-49-1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGHVII-49-1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGHVII-49-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-49-1 expression acts as an unfavorable survival marker, although some lineages such as STAD and HNSC show a favorable association.

KIRP, READ, and STAD are the cancer types where IGHVII-49-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.161	0.771	.002	48	view →
READ	DFS	Tertile	III,IV	0.082	0.749	<.001	36	view →
STAD	DFS	Quartile	IV	0.715	0.250	.008	34	view →
LIHC	OS	Tertile	II,III,IV	0.187	0.781	<.001	30	view →
LUAD	OS	Tertile	III,IV	0.293	0.673	.008	21	view →
KIRC	DFS	Tertile	IV	0.305	0.628	.021	18	view →
TGCT	OS	Tertile	All	0.845	0.968	.021	18	view →
HNSC	OS	Tertile	All	0.867	0.673	.045	9	view →
PCPG	DFS	Tertile	All	0.535	0.936	<.001	9	view →
COAD	DFS	Tertile	III,IV	0.111	0.649	.004	9	view →
CESC	OS	Tertile	II,III,IV	0.264	0.611	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGHVII-49-1–KIRP (OS)

Open the KIRP breakdown →