IGHVII-44-2

Across TCGA patient cohorts, IGHVII-44-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,306 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible IGHVII-44-2-associated GO terms across cancer lineages are Regulation of chromosome organization, Recombinational repair, and Negative regulation of chromosome organization. Each is linked with IGHVII-44-2 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGHVII-44-2-to-partner and partner-to-IGHVII-44-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome organization grouped by IGHVII-44-2-low versus IGHVII-44-2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-44-2→partner) and Y-score (partner→IGHVII-44-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of chromosome organization →	+0.076	+0.052	<.001	<.001	3	8
STAD	Recombinational repair →	+0.065	+0.053	<.001	<.001	3	8
STAD	Negative regulation of chromosome organization →	+0.083	+0.050	<.001	<.001	3	7
STAD	Positive regulation of DNA metabolic process →	+0.064	+0.056	<.001	<.001	3	7
STAD	RNA polymerase II preinitiation complex assembly →	+0.064	+0.057	<.001	<.001	3	7
STAD	Protein K48-linked ubiquitination →	+0.079	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,306 associations by consensus.

Regulation of chromosome organization by IGHVII-44-2 expression — STAD

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