IGHVII-40-1

Across TCGA pan-cancer cohorts, IGHVII-40-1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGHVII-40-1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IGHVII-40-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-40-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and THYM show a favorable association.

LIHC, STAD, and KIRP are the cancer types where IGHVII-40-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.470	0.735	<.001	102	view →
STAD	DFS	Tertile	All	0.486	0.673	.005	63	view →
KIRP	DFS	Tertile	II,III,IV	0.038	0.783	<.001	36	view →
KIRC	DFS	Tertile	IV	0.175	0.638	.041	18	view →
PCPG	DFS	Tertile	All	0.070	0.936	<.001	18	view →
SARC	OS	Tertile	All	0.661	0.844	.004	15	view →
SKCM	DFS	Quartile	All	0.300	0.171	.002	14	view →
READ	OS	Tertile	III,IV	0.287	0.772	.030	9	view →
THYM	OS	Tertile	All	1.000	0.689	.018	4	view →
HNSC	DFS	Tertile	All	0.469	0.670	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGHVII-40-1–LIHC (OS)

Open the LIHC breakdown →