IGHVII-40-1

Across TCGA pan-cancer cohorts, IGHVII-40-1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHVII-40-1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where IGHVII-40-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVII-40-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LIHC, COAD, and LUAD are the cancer types where IGHVII-40-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-40-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	All	+0.272	.006	1	view →
COAD	Female	All	−0.246	.038	1	view →
LUAD	All	All	+0.181	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGHVII-40-1–LIHC

Open the LIHC breakdown →