IGHVII-26-2

Across TCGA patient cohorts, IGHVII-26-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,835 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHVII-26-2-associated GO terms across cancer lineages are T cell proliferation, Positive regulation of leukocyte cell-cell adhesion, and Immunoglobulin production. Each is linked with IGHVII-26-2 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGHVII-26-2-to-partner and partner-to-IGHVII-26-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T cell proliferation grouped by IGHVII-26-2-low versus IGHVII-26-2-high in LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-26-2→partner) and Y-score (partner→IGHVII-26-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	T cell proliferation →	+0.060	+0.070	<.001	<.001	3	13
LUSC	Positive regulation of leukocyte cell-cell adhesion →	+0.061	+0.079	<.001	<.001	3	12
THCA	Immunoglobulin production →	+0.075	+0.019	<.001	<.001	3	12
LUSC	CD4-positive, alpha-beta T cell activation →	+0.054	+0.071	<.001	<.001	3	12
THCA	Positive regulation of T cell proliferation →	+0.070	+0.017	<.001	<.001	3	12
LUSC	CD4-positive, alpha-beta T cell differentiation →	+0.055	+0.089	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,835 associations by consensus.

T cell proliferation by IGHVII-26-2 expression — LUSC

Explore this box plot interactively →