IGHVII-26-2

Across TCGA pan-cancer cohorts, IGHVII-26-2 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGHVII-26-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHVII-26-2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHVII-26-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, STAD, and THYM are the cancer types where IGHVII-26-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.953	0.678	.006	105	view →
STAD	DFS	Tertile	All	0.389	0.575	.002	63	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	21	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
OV	OS	Tertile	III,IV	0.719	0.312	.042	18	view →
LUAD	DFS	Tertile	III,IV	0.621	0.285	.037	15	view →
COAD	DFS	Tertile	III,IV	0.106	0.412	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHVII-26-2–HNSC (DFS)

Open the HNSC breakdown →