IGHVII-22-1

Across TCGA pan-cancer cohorts, IGHVII-22-1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGHVII-22-1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IGHVII-22-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-22-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

KIRC, DLBC, and SKCM are the cancer types where IGHVII-22-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.448	0.681	.001	81	view →
DLBC	OS	Tertile	All	0.401	0.956	.001	33	view →
SKCM	DFS	Tertile	III,IV	0.616	0.203	<.001	27	view →
CESC	DFS	Tertile	All	0.944	0.805	.025	24	view →
LGG	DFS	Tertile	All	0.230	0.753	.039	12	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
KIRP	OS	Tertile	All	0.765	0.892	.022	6	view →
LIHC	OS	Tertile	III,IV	0.390	0.654	.034	6	view →
THCA	DFS	Tertile	III,IV	0.825	0.933	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGHVII-22-1–KIRC (OS)

Open the KIRC breakdown →