IGHVII-22-1

Across TCGA pan-cancer cohorts, IGHVII-22-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVII-22-1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where IGHVII-22-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHVII-22-1 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.

STAD and LUAD are the cancer types where IGHVII-22-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-22-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	−0.346	.044	2	view →
LUAD	All	All	+0.114	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVII-22-1–STAD

Open the STAD breakdown →