IGHVII-15-1

Across TCGA patient cohorts, IGHVII-15-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,253 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHVII-15-1-associated GO terms across cancer lineages are Thymic T cell selection, Interleukin-10 production, and Positive regulation of natural killer cell differentiation. Each is linked with IGHVII-15-1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHVII-15-1-to-partner and partner-to-IGHVII-15-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Thymic T cell selection grouped by IGHVII-15-1-low versus IGHVII-15-1-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-15-1→partner) and Y-score (partner→IGHVII-15-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Thymic T cell selection →	+0.100	+0.009	<.001	.003	3	5
STAD	Interleukin-10 production →	+0.088	+0.050	<.001	.001	3	4
STAD	Positive regulation of natural killer cell differentiation →	+0.078	+0.059	<.001	.002	3	4
STAD	T cell differentiation in thymus →	+0.104	+0.034	<.001	.005	2	5
THYM	Positive thymic T cell selection →	+0.116	+0.259	<.001	<.001	3	4
STAD	Regulation of lymphocyte apoptotic process →	+0.106	+0.051	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

Thymic T cell selection by IGHVII-15-1 expression — THCA

Explore this box plot interactively →