IGHVII-1-1

Across TCGA pan-cancer cohorts, IGHVII-1-1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGHVII-1-1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IGHVII-1-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVII-1-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

BLCA, KIRC, and SKCM are the cancer types where IGHVII-1-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.101	0.627	<.001	72	view →
KIRC	DFS	Tertile	All	0.488	0.807	<.001	48	view →
SKCM	OS	Tertile	All	0.305	0.785	<.001	36	view →
LIHC	OS	Tertile	All	0.331	0.690	.011	30	view →
SARC	OS	Tertile	All	0.022	0.861	<.001	27	view →
GBM	DFS	Tertile	All	0.066	0.257	.019	18	view →
HNSC	DFS	Tertile	All	0.943	0.305	.028	15	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
STAD	DFS	Tertile	All	0.534	0.670	.038	9	view →
LGG	DFS	Tertile	All	0.387	0.758	.040	9	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGHVII-1-1–BLCA (DFS)

Open the BLCA breakdown →