Across TCGA patient cohorts, IGHV7-81 protein abundance is significantly associated with the RNA expression of many other genes, with 650 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV7-81-associated genes across cancer lineages are PTPN5, ADAMTS8, and LMO2. Each is linked with IGHV7-81 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV7-81-to-partner and partner-to-IGHV7-81 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV7-81→partner) and Y-score (partner→IGHV7-81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTPN5 →	+0.165	+1.623	.003	<.001	3	1
BRCA	ADAMTS8 →	+0.527	+1.419	.005	.009	3	1
BRCA	LMO2 →	+0.560	+1.776	.007	.001	3	1
BRCA	TRMO →	+0.385	+1.296	.004	.008	3	1
BRCA	SRP14 →	+0.466	+1.459	<.001	.005	3	1
BRCA	SEC11A →	+0.390	+1.261	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 650 associations by consensus.

Exploration

IGHV7-81 survival (RNA) · tumor vs normal (RNA) · all IGHV7-81 data types