Across TCGA patient cohorts, IGHV7-81 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV7-81-associated genes across cancer lineages are TFDP1P3, MAPK7, and MIR1273H. Each is linked with IGHV7-81 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV7-81-to-partner and partner-to-IGHV7-81 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV7-81→partner) and Y-score (partner→IGHV7-81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFDP1P3 →	+0.218	+3.686	<.001	.002	3	2
UCEC	MAPK7 →	+0.607	+3.223	.004	.009	2	2
UCEC	MIR1273H →	+0.293	+3.399	<.001	.005	3	1
UCEC	ACOD1 →	+0.196	+3.845	<.001	.002	3	1
UCEC	KRT17P1 →	+0.114	+2.847	.005	.009	3	1
UCEC	ADIRF →	+0.034	+5.478	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Exploration

IGHV7-81 survival (RNA) · tumor vs normal (RNA) · all IGHV7-81 data types