Across TCGA patient cohorts, IGHV7-81 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV7-81-associated genes across cancer lineages are Heregulin, C-Raf_pS338, and ERK2. Each is linked with IGHV7-81 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV7-81-to-partner and partner-to-IGHV7-81 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV7-81→partner) and Y-score (partner→IGHV7-81) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.180	-3.000	.011	.036	3	1
UCEC	C-Raf_pS338 →	-0.144	-3.000	.002	.037	3	1
UCEC	ERK2 →	+0.320	+3.000	.004	.037	1	2
UCEC	Mre11 →	-0.141	-3.000	.004	.037	2	1
UCEC	Myosin-IIa_pS1943 →	+0.290	+3.013	.014	.019	2	1
UCEC	Annexin-1 →	+0.867	+3.000	.004	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

IGHV7-81 survival (RNA) · tumor vs normal (RNA) · all IGHV7-81 data types