IGHV7-34-1

Across TCGA pan-cancer cohorts, IGHV7-34-1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGHV7-34-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV7-34-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV7-34-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and LUAD are the cancer types where IGHV7-34-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.800	0.702	<.001	142	view →
BRCA	OS	Median	All	0.621	0.534	<.001	78	view →
LUAD	DFS	Median	II,III,IV	0.584	0.303	<.001	68	view →
SKCM	OS	Median	III,IV	0.535	0.270	<.001	67	view →
GBM	DFS	Tertile	All	0.079	0.263	<.001	45	view →
MESO	OS	Tertile	III,IV	0.510	0.274	.003	43	view →
STAD	DFS	Tertile	III,IV	0.476	0.670	.005	42	view →
COAD	DFS	Quartile	All	0.906	0.643	<.001	36	view →
UVM	DFS	Tertile	All	0.335	0.779	.004	27	view →
CESC	DFS	Median	All	0.796	0.675	.007	16	view →
ESCA	OS	Tertile	III,IV	0.630	0.350	.015	12	view →
KIRP	OS	Tertile	All	0.444	0.751	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGHV7-34-1–HNSC (OS)

Open the HNSC breakdown →