IGHV7-34-1

Across TCGA pan-cancer cohorts, IGHV7-34-1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGHV7-34-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV7-34-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV7-34-1 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

LUAD, COAD, and LIHC are the cancer types where IGHV7-34-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV7-34-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.494	<.001	7	view →
COAD	Female	III,IV	−1.398	.003	6	view →
LIHC	Male	All	−0.211	<.001	6	view →
KIRC	Male	All	+0.250	<.001	4	view →
BRCA	Female	All	−0.203	.004	4	view →
PAAD	Female	All	−1.040	.044	2	view →
READ	Male	All	−1.023	.005	2	view →
CHOL	All	II,III,IV	−0.255	.009	2	view →
ESCA	All	All	+0.256	.038	1	view →
KIRC	Female	IV	−0.216	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

IGHV7-34-1–LUAD

Open the LUAD breakdown →