IGHV7-27

Across TCGA pan-cancer cohorts, IGHV7-27 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGHV7-27 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV7-27 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV7-27 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, UVM, and BRCA are the cancer types where IGHV7-27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.526	0.267	<.001	139	view →
UVM	DFS	Tertile	All	0.335	0.779	.004	54	view →
BRCA	OS	Median	All	0.973	0.951	.003	50	view →
SKCM	DFS	Tertile	All	0.767	0.575	.003	43	view →
GBM	OS	Tertile	All	0.091	0.417	<.001	27	view →
STAD	DFS	Median	All	0.556	0.699	.006	27	view →
CHOL	DFS	Tertile	All	0.830	0.142	.011	21	view →
LUAD	OS	Quartile	II,III,IV	0.885	0.650	.004	21	view →
DLBC	DFS	Quartile	All	0.537	1.000	.015	19	view →
TGCT	DFS	Median	All	0.767	0.561	.006	16	view →
LIHC	DFS	Tertile	II,III,IV	0.551	0.389	.030	9	view →
KIRP	DFS	Tertile	All	0.520	0.824	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGHV7-27–HNSC (OS)

Open the HNSC breakdown →