IGHV7-27

Across TCGA pan-cancer cohorts, IGHV7-27 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV7-27’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV7-27 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV7-27 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGHV7-27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV7-27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.233	<.001	9	view →
LUAD	Male	All	+1.135	<.001	6	view →
STAD	Male	All	−0.814	.013	4	view →
BRCA	Female	II,III,IV	−0.300	.006	4	view →
READ	All	All	−1.552	.001	3	view →
LIHC	Male	All	−0.164	.006	3	view →
KIRC	All	All	+0.186	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV7-27–COAD

Open the COAD breakdown →