IGHV4OR15-8

Across TCGA pan-cancer cohorts, IGHV4OR15-8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV4OR15-8 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher IGHV4OR15-8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV4OR15-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

UVM, HNSC, and SKCM are the cancer types where IGHV4OR15-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.315	0.864	<.001	99	view →
HNSC	DFS	Tertile	All	0.813	0.647	<.001	96	view →
SKCM	DFS	Median	All	0.851	0.676	<.001	62	view →
BRCA	OS	Tertile	All	0.981	0.951	.004	38	view →
OV	DFS	Median	III,IV	0.406	0.340	.028	30	view →
CHOL	DFS	Tertile	All	0.812	0.237	.003	29	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
PAAD	OS	Median	II,III,IV	0.667	0.438	.002	17	view →
UCEC	OS	Quartile	IV	0.852	0.374	.030	16	view →
MESO	OS	Tertile	III,IV	0.659	0.211	.022	16	view →
LIHC	OS	Tertile	All	0.933	0.753	.006	15	view →
READ	DFS	Quartile	All	0.953	0.485	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV4OR15-8–UVM (OS)

Open the UVM breakdown →