IGHV4OR15-8

Across TCGA pan-cancer cohorts, IGHV4OR15-8 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV4OR15-8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV4OR15-8 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV4OR15-8 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and READ are the cancer types where IGHV4OR15-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV4OR15-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.476	<.001	10	view →
LUAD	All	All	+0.804	<.001	8	view →
READ	All	II,III,IV	−0.937	.006	4	view →
HNSC	All	III,IV	+0.428	.022	3	view →
ESCA	All	II,III,IV	+1.484	.008	2	view →
THCA	Male	II,III,IV	+0.148	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV4OR15-8–COAD

Open the COAD breakdown →