IGHV4-55

Across TCGA patient cohorts, IGHV4-55 mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHV4-55-associated genes across cancer lineages are CDKN2AIPNLP2, RPL21P41, and TSPY8. Each is linked with IGHV4-55 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-55-to-partner and partner-to-IGHV4-55 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN2AIPNLP2 grouped by IGHV4-55-low versus IGHV4-55-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-55→partner) and Y-score (partner→IGHV4-55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDKN2AIPNLP2 →	+0.059	+3.038	.006	.004	3	2
SKCM	RPL21P41 →	+0.135	+2.784	.009	.003	3	2
LUAD	TSPY8 →	+0.119	+5.155	<.001	.002	3	2
UCEC	RNA5SP86 →	+0.715	+3.562	<.001	.004	3	2
UCEC	LYPLA1P1 →	+0.096	+4.464	<.001	.005	3	2
COAD	SOD1P2 →	+0.228	+5.145	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

CDKN2AIPNLP2 by IGHV4-55 expression — SKCM

Explore this box plot interactively →