IGHV4-55

Across TCGA pan-cancer cohorts, IGHV4-55 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated IGHV4-55 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV4-55 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV4-55 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV4-55 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.684	0.523	<.001	149	view →
SKCM	DFS	Median	III,IV	0.613	0.398	<.001	87	view →
UCEC	OS	Tertile	III,IV	0.715	0.278	.002	62	view →
BRCA	DFS	Quartile	All	0.967	0.907	.001	39	view →
UVM	DFS	Tertile	All	0.574	0.798	.031	38	view →
SARC	DFS	Quartile	All	0.731	0.446	.001	32	view →
LUAD	OS	Median	II,III,IV	0.698	0.485	.003	23	view →
LGG	OS	Tertile	All	0.664	0.820	.008	21	view →
READ	DFS	Median	IV	0.772	0.379	.006	20	view →
UCS	OS	Tertile	II,III,IV	0.823	0.508	.013	18	view →
ACC	OS	Tertile	II,III,IV	0.552	0.810	.031	15	view →
COAD	DFS	Median	All	0.693	0.416	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

IGHV4-55–HNSC (DFS)

Open the HNSC breakdown →