IGHV4-4

Across TCGA pan-cancer cohorts, IGHV4-4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGHV4-4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV4-4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV4-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where IGHV4-4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.663	1.000	.007	13	view →
PDAC	OS	Median	III,IV	0.631	0.990	.007	12	view →
UCEC	DFS	Median	All	0.852	0.980	.009	10	view →
HNSC	DFS	Quartile	III,IV	0.989	0.728	.007	8	view →
CCRCC	DFS	Median	IV	0.861	0.143	.017	6	view →
LSCC	DFS	Median	All	0.907	0.464	.009	4	view →
GBM	DFS	Quartile	All	0.468	0.231	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHV4-4–LUAD (OS)

Open the LUAD breakdown →