IGHV4-31

Across TCGA pan-cancer cohorts, IGHV4-31 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV4-31 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGHV4-31 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV4-31 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LUSC, LUAD, and SKCM are the cancer types where IGHV4-31 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.202	0.745	.001	36	view →
LUAD	OS	Median	All	0.611	0.812	.039	2	view →
SKCM	DFS	Median	All	1.000	0.614	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IGHV4-31–LUSC (OS)

Open the LUSC breakdown →