IGHV4-31

Across TCGA pan-cancer cohorts, IGHV4-31 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGHV4-31 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGHV4-31 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV4-31 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where IGHV4-31 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.523	0.856	.003	10	view →
PDAC	OS	Median	III,IV	0.550	1.000	.038	7	view →
LUAD	OS	Quartile	III,IV	0.721	1.000	.031	5	view →
CCRCC	DFS	Median	III,IV	1.000	0.838	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGHV4-31–LSCC (DFS)

Open the LSCC breakdown →