IGHV4-31

Across TCGA pan-cancer cohorts, IGHV4-31 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHV4-31’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV4-31 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types IGHV4-31 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where IGHV4-31 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV4-31 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.049	<.001	10	view →
HNSC	All	III,IV	−0.942	<.001	8	view →
LUAD	Female	II,III,IV	−0.679	<.001	6	view →
LSCC	Male	All	−0.558	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHV4-31–COAD

Open the COAD breakdown →