IGHV3OR16-9

Across TCGA patient cohorts, IGHV3OR16-9 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3OR16-9-associated genes across cancer lineages are UBL5P3, RNA5SP394, and DPPA5. Each is linked with IGHV3OR16-9 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-9-to-partner and partner-to-IGHV3OR16-9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBL5P3 grouped by IGHV3OR16-9-low versus IGHV3OR16-9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-9→partner) and Y-score (partner→IGHV3OR16-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBL5P3 →	+0.384	+5.133	<.001	.008	3	2
SKCM	RNA5SP394 →	+0.412	+4.159	<.001	.002	3	1
SKCM	DPPA5 →	+0.528	+3.533	<.001	.007	3	1
SKCM	MCCD1 →	+0.057	+4.290	<.001	<.001	3	1
SKCM	KRTAP27-1 →	+0.055	+4.199	<.001	.009	3	1
SKCM	MIR626 →	+0.416	+4.970	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

UBL5P3 by IGHV3OR16-9 expression — UCEC

Explore this box plot interactively →