IGHV3OR16-9

Across TCGA pan-cancer cohorts, IGHV3OR16-9 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-9 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-9 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3OR16-9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.665	0.542	<.001	144	view →
SKCM	OS	Median	All	0.405	0.276	<.001	132	view →
BRCA	DFS	Tertile	All	0.969	0.913	<.001	96	view →
UVM	DFS	Tertile	All	0.261	0.798	<.001	78	view →
KIRP	OS	Quartile	All	0.322	0.759	<.001	25	view →
DLBC	DFS	Tertile	IV	0.128	1.000	.017	23	view →
COAD	DFS	Quartile	IV	0.562	0.223	.012	20	view →
GBM	DFS	Tertile	All	0.108	0.317	.002	18	view →
LUAD	DFS	Quartile	III,IV	0.771	0.295	.015	16	view →
UCS	DFS	Quartile	II,III,IV	0.609	0.245	.027	16	view →
SARC	DFS	Tertile	All	0.599	0.466	.016	12	view →
LGG	DFS	Tertile	All	0.660	0.839	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGHV3OR16-9–HNSC (DFS)

Open the HNSC breakdown →