IGHV3OR16-7

Across TCGA pan-cancer cohorts, IGHV3OR16-7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-7 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher IGHV3OR16-7 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-7 expression acts as an unfavorable survival marker, although some lineages such as BRCA and CHOL show a favorable association.

BRCA, DLBC, and CHOL are the cancer types where IGHV3OR16-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.973	0.935	.004	86	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	36	view →
CHOL	DFS	Quartile	All	0.805	0.278	.007	30	view →
CESC	OS	Median	All	0.866	0.754	.009	24	view →
LGG	DFS	Tertile	All	0.215	0.756	<.001	21	view →
GBM	OS	Tertile	All	0.235	0.427	.018	18	view →
UCS	OS	Tertile	IV	0.269	0.624	.042	18	view →
KIRP	DFS	Tertile	All	0.524	0.835	.029	15	view →
READ	OS	Median	IV	1.000	0.520	.011	13	view →
PAAD	OS	Quartile	II,III,IV	0.728	0.458	.007	12	view →
LIHC	DFS	Tertile	III,IV	0.721	0.326	.036	12	view →
STAD	DFS	Tertile	All	0.450	0.644	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV3OR16-7–BRCA (DFS)

Open the BRCA breakdown →