IGHV3OR16-7

Across TCGA pan-cancer cohorts, IGHV3OR16-7 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-7’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV3OR16-7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-7 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

LUAD, COAD, and READ are the cancer types where IGHV3OR16-7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.718	<.001	8	view →
COAD	Female	All	−1.057	<.001	7	view →
READ	All	All	−0.848	.001	3	view →
STAD	Male	IV	−1.740	.025	2	view →
LUSC	All	All	+0.285	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHV3OR16-7–LUAD

Open the LUAD breakdown →