IGHV3OR16-6

Across TCGA pan-cancer cohorts, IGHV3OR16-6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3OR16-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3OR16-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.466	0.321	<.001	144	view →
SKCM	OS	Median	All	0.416	0.268	<.001	143	view →
BRCA	OS	Tertile	All	0.979	0.939	<.001	77	view →
UVM	OS	Tertile	II,III,IV	0.189	0.729	.001	63	view →
CHOL	DFS	Tertile	All	0.779	0.232	<.001	43	view →
KIRP	OS	Quartile	All	0.342	0.778	<.001	40	view →
LGG	DFS	Tertile	All	0.275	0.834	<.001	36	view →
LIHC	DFS	Tertile	II,III,IV	0.686	0.385	.015	27	view →
GBM	OS	Tertile	All	0.121	0.455	<.001	18	view →
DLBC	DFS	Median	All	0.360	1.000	.007	13	view →
PAAD	DFS	Median	II,III,IV	0.508	0.353	.019	11	view →
LUAD	OS	Median	II,III,IV	0.676	0.502	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3OR16-6–HNSC (OS)

Open the HNSC breakdown →