IGHV3OR16-6

Across TCGA pan-cancer cohorts, IGHV3OR16-6 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3OR16-6 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-6 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3OR16-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.680	<.001	12	view →
LUAD	Female	All	+1.213	<.001	6	view →
BRCA	Female	II,III,IV	−0.371	.008	4	view →
READ	All	All	−1.772	<.001	3	view →
KIRC	All	All	+0.294	.005	2	view →
LUSC	Male	All	+0.574	.037	1	view →
HNSC	All	III,IV	+0.460	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV3OR16-6–COAD

Open the COAD breakdown →