IGHV3OR16-15

Across TCGA patient cohorts, IGHV3OR16-15 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,931 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3OR16-15-associated GO terms across cancer lineages are Antibacterial humoral response, B cell receptor signaling pathway, and Complement activation. Each is linked with IGHV3OR16-15 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-15-to-partner and partner-to-IGHV3OR16-15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antibacterial humoral response grouped by IGHV3OR16-15-low versus IGHV3OR16-15-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-15→partner) and Y-score (partner→IGHV3OR16-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antibacterial humoral response →	+0.171	+0.730	<.001	<.001	3	29
CHOL	B cell receptor signaling pathway →	+0.078	+0.594	<.001	.005	2	28
THCA	Complement activation →	+0.159	+0.683	<.001	<.001	3	27
THCA	Complement activation, classical pathway →	+0.199	+0.692	<.001	<.001	3	27
THCA	B cell mediated immunity →	+0.097	+0.779	<.001	<.001	3	27
THCA	Antimicrobial humoral response →	+0.111	+0.716	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,931 associations by consensus.

Antibacterial humoral response by IGHV3OR16-15 expression — THCA

Explore this box plot interactively →