IGHV3OR16-15

Across TCGA pan-cancer cohorts, IGHV3OR16-15 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-15 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-15 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where IGHV3OR16-15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.666	0.542	<.001	144	view →
SKCM	DFS	Tertile	All	0.764	0.541	<.001	86	view →
ACC	DFS	Tertile	II,III,IV	0.010	0.582	<.001	81	view →
LUAD	DFS	Tertile	II,III,IV	0.679	0.286	.001	42	view →
GBM	OS	Tertile	All	0.215	0.426	.001	36	view →
BRCA	OS	Tertile	All	0.977	0.949	.012	30	view →
KICH	DFS	Tertile	III,IV	0.043	0.774	.005	27	view →
LGG	OS	Tertile	All	0.621	0.895	<.001	24	view →
BLCA	OS	Tertile	All	0.677	0.476	.019	22	view →
CESC	DFS	Quartile	All	0.818	0.674	.016	20	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	18	view →
PAAD	DFS	Tertile	II,III,IV	0.515	0.272	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV3OR16-15–HNSC (DFS)

Open the HNSC breakdown →